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International Journal of Clinical Pharmacology & Pharmacotherapy Volume 1 (2016), Article ID 1:IJCPP-111, 3 pages
https://doi.org/10.15344/2456-3501/2016/111
Case Report
Unexpected Baclofen Subdural Infusion in a Patient who Carries an Internal Pump for Intrathecal Infusion: A Case Report

Maurizio Barca1* and Monica Montopoli2

1U.O. di Terapia Antalgica, Ospedale dell'Angelo. Az. ULSS12 Veneziana, Venice, Italy
2Department of Pharmaceutical and Pharmacological Sciences, Largo Meneghetti 2, University of Padova, Padova, Italy
Dr. Maurizio Barca MD U.O. di Terapia Antalgica, Ospedale dell'Angelo. Az. ULSS12 Veneziana, Venice, Italy, Tel +39 329 110 4897; E-mail: mauriziobarca@yahoo.com
19 November 2015; 03 June 2016; 05 June 2016
Barca M, Montopoli M (2016) Unexpected Baclofen Subdural Infusion in a Patient who Carries an Internal Pump for Intrathecal Infusion: A Case Report. Int J Clin Pharmacol Pharmacother 1: 111. doi: https://doi.org/10.15344/2456-3501/2016/111

Abstract

Objective: We report a case of intrathecal baclofen infusion pump implantation complicated by migration of the catheter tip. Subdural migration, of the intrathecal catheter tip, in who has been having an infusion pump for years and is experiencing swinging dosage related effects it is not the first thing one takes into consideration. A case of subdural migration of intrathecal catheters is presented.
Methods: Subsequent X-ray and computed tomography evaluations of the catheter system revealed pooling of contrast medium outside of the intrathecal space, in the lumbar subdural region of the vertebral channel and therefore migration of the pump catheter tip.
Results: The spinal catheter was subsequently revised, and the patient made a full recovery. From few days after surgery, the patients spasticity improved and up to now (six months later), he has been experiencing no further complications, is requiring an average baclofen dosage of 150 mcg/day.
Conclusion: The possible migration of an intrathecal catheter into the subdural space should be included as differential diagnosis in a patient who experiences a lack of drug effect, despite increases in dosage, after years from pump implantation. We recommend the use of the CT scan, after contrast injection, to detect the distal catheter tip and confirm a normal diffusion into the subarachnoid space.