Table 2: Case Definition for Multisystem Inflammatory Syndrome in Children (MIS-C).
*: Fever >38.0°C for ≥24 hours, or report of subjective fever lasting ≥24 hours.
§: Including, but not limited to, one or more of the following: an elevated C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, procalcitonin, d-dimer, ferritin, lactic acid dehydrogenase (LDH), or interleukin 6 (IL-6), elevated neutrophils, reduced lymphocytes and low albumin.
Centers for Disease Control and Prevention (CDC) 2021.
| •An individual aged <21 years presenting with fever*, laboratory evidence of inflammation§, and evidence of clinically severe illness requiring hospitalization, with multisystem (>2) organ involvement (cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic or neurological); AND |
| •No alternative plausible diagnoses; AND |
| •Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test; or COVID-19 exposure within the 4 weeks prior to the onset of symptoms. |