Table 8: AUC comparison of Savonix subtests with the lower and higher reference AUCs. For MCI vs. AD discrimination.
Tests in bold: Selected tests to detect AD from MCI. AUC: Area under the ROC curve, CI: confidence interval. *: p value of DeLong’s ROC comparison tests.
Subtests AUC (95% CI) Comparison with MinAUC (Verbal Interference Part 1’s)
p value*
Comparison with MaxAUC (AUC for Total 6 Domain score: 0.832)
p value*
Immediate Verbal Learning 0.708 (0.564-0.851) p < 0.05 p<0.05
Delayed Verbal Learning 0.647 (0.490-0.805) p=0.208 n.s. p<0.001
Verbal Interference Part 1 0.490 (0.319-0.661) n.a. n.a.
Verbal Interference Part 2 0.765 (0.625-0.906) p<0.05 p=0.363 n.s.
Trail Making Part 1 0.810 (0.688-0.931) P<0.01 p=0.723 n.s.
Trail Making Part 2 0.793 (0.666-0.921) P<0.01 P=0.332 n.s.
Digit Span Forward 0.676 (0.523-0.829) p=0.138 n.s. p=0.127 n.s.
Digit Span Reverse 0.666 (0.528-0.804) p=0.087 n.s. p<0.05
Maze 1 0.642 (0.482-0.802) P=0.241 n.s. P<0.05
Maze 2 0.577 (0.410-0.744) p=0.526 n.s. P<0.01
Complex Figure 0.769 (0.634-0.903) P<0.01 P=0.388 n.s.