Table 2: Discriminant indices of Savonix test, MMSE, ADAS-Cog, and CDR Sum of Boxes (CDRSB) to detect AD from MCI. Summary of logistic regression for logistic regressions with the predictor tests adjusted education years.
*: MMSE was used for diagnosis. AUC: Area Under the Receiver Operating Characteristic Curve. CI: Confidence Interval. PPV: Positive Predictive Values. NPV: Negative Predictive Values. B: regression coefficients. SD: Standard Deviations for the regression coefficients. Wald Chisq: Wald Chi square statistics. P value: P values for Wald Chi square statistics. Selected 3 subtests: Trail Making 1; Trail Making 2: and Complex Figure.
Tests | AUC (95% CI) | Sensitivity | Specificity | PPV | NPV | B | | SD | Wald Chisq | P value |
Savonix 11 subtests total score | 0.866 | 0.810 | 0.857 | 0.810 | 0.857 | Test score | -1.27358 | 0.39176 | 10.5685 | p<0.01 |
(0.760-0.972) | | | | | Education | 0.071 | 0.112 | 0.396 | p = 0.529 n.s. |
Savonix Selected 3 subtest total score | 0.855 | 0.714 | 0.929 | 0.882 | 0.813 | Test score | -2.39999 | 0.7702 | 9.784 | p<0.01 |
(0.744-0.938) | | | | | Education | 0.109 | 0.112 | 0.961 | p = 0.327 n.s. |
MMSE* | 0.991 | 0.952 | 1 | 1 | 0.966 | Test score | -2.567 | 1.1193 | 5.2601 | p<0.05 |
(0.971-1) | | | | | Education | 0.242 | 0.353 | 0.469 | p = 0.469 n.s. |
ADAS-Cog | 0.841 | 0.750 | 0.821 | 0.750 | 0.821 | Test score | 0.206 | 0.064 | 10.492 | p<0.01 |
(0.722-0.9601) | | | | | Education | 0.107 | 0.120 | 0.798 | p = 0.372 n.s. |
CDRSB | 0.832 | 0.900 | 0.643 | 0.643 | 0.900 | Test score | 0.935 | 0.354 | 6.993 | p<0.01 |
(0.721-0.944) | | | | | Education | 0.213 | 0.354 | 2.864 | p = 0.091 n.s. |