Table 10: AUC comparison of Savonix subtests with the lower and higher reference AUCs. For Normal vs. AD discrimination.
Tests in bold: Selected tests to detect AD from Normal. AUC: Area under the ROC curve. CI: confidence interval. *: p value of DeLong’s ROC comparison tests.
Tests AUC (95% CI) Comparison with MinAUC (Verbal Interference Part 1’s)
p value*
Comparison with MaxAUC (AUC for Total 11 test score: 0.948)
p value
Immediate Verbal Learning 0.885 (0.828-0.941) p =0.064 n.s. p<0.01
Delayed Verbal Learning 0.833 (0.738-0.929) p<0.05 p<0.01
Verbal Interference Part 1 0.511 (0.367-0.655)
Verbal Interference Part 2 0.755 (0.642-0.869) p<0.05 p<0.001
Trail Making Part 1 0.894 (0.851-0.937) P<0.0001 p<0.05
Trail Making Part 2 0.924 (0.880-0.969) P<0.0001 P=0.084 n.s.
Digit Span Forward 0.627 (0.492-0.762) p=0.276 n.s. p<0.0001
Digit Span Reverse 0.596 (0.502-0.691) p=0.294 n.s. p<0.0001
Maze 1 0.720 (0.629-0.810) p<0.05 p<0.0001
Maze 2 0.791 (0.693-0.887) p<0.01 p<0.01
Complex Figure 0.907 (0.869-0.945) P<0.0001 P<0.118 n.s.