Table 2: Parameters for insulin action before and after treatment.

Data as median (25^th, 75^th interquartile range); HOMA-IR: homeostasis model assessment for insulin resistance; HOMA-B: homeostasis model assessment for β-cell function
^a represented by acute insulin response to glucose load (AIRg (U/min)) in frequent sample intravenous glucose tolerance test.
^b represented by insulin/glucose slope in modified low-dose graded glucose infusion.

Parameter	Baseline	After treatment	p value
First phase insulin secretion a	15.5 (5.1-40.7)	49.0 (3.9- 72.1)	0.0880
Second phase insulin secretion b	0.045(0.006-0.087)	0.077(0.046-0.118)	0.0436
HOMA-B	3.49 (-1.55-7.15)	6.94(3.41-18.8)	0.0388
HOMA-IR	0.94(0.26-3.04)	1.16 (0.53-2.95)	0.5481
Insulin sensitivity (10-4×min-1×pmol-1×l-1)	2.5 (0.98-4.82)	2.2(1.40-3.85)	0.3871
Glucose effectiveness (min-1)	0.016 (0.011-0.021)	0.014 (0.007-0.017)	0.1101